Safe disposal guidelines for unwanted pharmaceuticals during and after emergencies are detailed in this document. Various disposal methods are cited, such as high-temperature incineration, encapsulation, and burial in lined landfills, emphasizing safety and minimizing environmental harm. Also discussed are methods for pharmaceutical waste categorization, proper transportation and handling procedures, along with recommendations for stakeholder involvement in managing the process and assisting with decision making. Practical advice on organizing work teams, ensuring their safety, and raising public awareness about the safe disposal of pharmaceuticals is also discussed. This guidebook provides a comprehensive framework for healthcare facilities, NGOs, and governmental organizations to help prevent pharmaceutical misuse and environmental contamination during crisis situations.